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As a key member of the ubiquitin-specific protease (USP) family, USP8 preserves substrate stability via its deubiquitinating activity, and its dysregulation drives the initiation and progression of diverse malignanciesby stabilizing oncogenic substrates to promote tumor proliferation, invasion, and metastasiswhile its mutations can contribute to benign pituitary adenomas

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Obesity remains a critical health issue in the United States, with nearly 42.4% of adults facing obesity

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